Evolution of IgE responses to multiple allergen components throughout childhood

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Patterns of IgE responses to multiple allergen components and clinical symptoms at age 11 years

BACKGROUND The relationship between sensitization to allergens and disease is complex. OBJECTIVE We sought to identify patterns of response to a broad range of allergen components and investigate associations with asthma, eczema, and hay fever. METHODS Serum specific IgE levels to 112 allergen components were measured by using a multiplex array (Immuno Solid-phase Allergen Chip) in a popula...

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Exploring the temporal development of childhood IgE profiles to allergen components

UNLABELLED BACKGROUND Children often develop allergies that may or not persist into adulthood. Although the different allergic symptoms over time have been well documented, the underlying pattern of sensitization to various proteins and subsequent allergy development is unexplored.The aim was to study the sensitization pattern to allergen components over time from infancy to adulthood in a g...

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Allergy testing in childhood: using allergen-specific IgE tests.

A variety of triggers can induce common pediatric allergic diseases which include asthma, allergic rhinitis, atopic dermatitis, food allergy, and anaphylaxis. Allergy testing serves to confirm an allergic trigger suspected on the basis of history. Tests for allergen-specific immunoglobulin E (IgE) are performed by in vitro assays or skin tests. The tests are excellent for identifying a sensitiz...

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Allergy Testing in Childhood: Using Allergen-Specific IgE Tests abstract

A variety of triggers can induce common pediatric allergic diseases which include asthma, allergic rhinitis, atopic dermatitis, food allergy, and anaphylaxis. Allergy testing serves to confirm an allergic trigger suspected on the basis of history. Tests for allergen-specific immunoglobulin E (IgE) are performed by in vitro assays or skin tests. The tests are excellent for identifying a sensitiz...

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Specific IgE response to different grass pollen allergen components in children undergoing sublingual immunotherapy

UNLABELLED BACKGROUND Grass pollen is a major cause of respiratory allergy worldwide and contain a number of allergens, some of theme (Phl p 1, Phl p 2, Phl p 5, and Phl 6 from Phleum pratense, and their homologous in other grasses) are known as major allergens. The administration of grass pollen extracts by immunotherapy generally induces an initial rise in specific immunoglobulin E (sIgE) ...

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ژورنال

عنوان ژورنال: Journal of Allergy and Clinical Immunology

سال: 2018

ISSN: 0091-6749

DOI: 10.1016/j.jaci.2017.11.064